NAD+ (nicotinamide adenine dinucleotide)
The Complete Guide (Updated for 2018)
Nicotinamide adenine dinucleotide (NAD+) is a co-enzyme found in all living cells. It’s one of the fundamental building blocks of life because it turns nutrients into energy.
As we age, NAD+ levels decline. But now, scientists have found a way to boost NAD+ levels in the body. And research suggests that boosting NAD+ levels through supplementation increases energy levels and provides what many are calling “the fountain of youth”.
With so much information about NAD+ floating around, how do you digest all the science and make the right decision for you?
This complete guide will help you find out everything you need to know including:
We suggest consulting with your healthcare physician as the supplements and/or products discussed are not intended to diagnose, treat, cure, or prevent any disease. The information provided is not intended to substitute for consultations with your healthcare provider, nor should it be considered medical advice specific to your health condition.
What Exactly Is NAD+?
According to Sciencemag.com, NAD+ (nicotinamide adenine dinucleotide) is a co-enzyme which is found in all living cells, and is essential for life and is as important to our cells as food, water, and oxygen. NAD+ is essential for many critical cell functions, such as energy metabolism, mitochondrial function, DNA repair, regulation of circadian rhythm and gene expression. Science has shown that NAD+ levels decline as we age, the higher our NAD+ levels are the better our cells function.
Scientists believe that both the health and the lifespan of humans can be improved with NAD+ supplementation.
A Brief History
NAD+ was first discovered in 1906—more than 110 years ago—by scientists who were researching fermentation.
The medical importance of NAD+ was originally established when the disease pellagra was discovered. Pellagra is a disease characterized by dermatitis, dementia, diarrhea and, eventually death. While pellagra is not a common disease in the developed world, NAD+ has been shown to be helpful in slowing the aging process as well as halting age-associated diseases.
As early as the 1930’s, administration of NAD+ precursors were found to improve the neurological state of dementia patients. Pharmacological dosages of NAD+ has been found to provide dramatic therapeutic benefits for diseases such as MS, Type I diabetes, colitis, rheumatoid arthritis and schizophrenia, providing potent anti-inflammatory effects.
Administration of NAD+ in therapeutic dosages has been found to reduce cellular injury in a number of diseases, improving cell viability by enhancing the activities of sirtuins and improving energy metabolism.
In short, science shows that NAD+ helps the body function better while aging. In order to understand “how” it works, you first need to understand what happens to the body as we age.
Power to the Mitochondria
Mitochondria are essentially tiny batteries within each cell that are the source of cellular energy. To make that energy, a series of chemical reactions must take place within the mitochondira. NAD+ is a major component of these reactions, which produce the energy known as “ATP”. A reduced level of NAD+ leads to lower ATP production which is critical for our bodies to function properly.
Loss of mitochondrial function is a hallmark of the aging process as well as age-related diseases. Some studies of NAD+ have shown a link between mitochondrial function and NAD+ metabolism.
Initially, short-term NAD+ supplementation of mice who suffered loss of mitochondrial function found a restoration of some reversible aspects of aging, leading scientists to believe that NAD+ could induce life-span extension and lessen aging effects in humans as well.
Today, NAD+ is considered a “courier” in the metabolism process, shuttling important information between the body’s molecules, allowing them to effectively react with one another.
NAD+ can also help the body during periods of stress, allowing the health of DNA to remain stable, and regulating the body’s circadian rhythms.
Recent Science Supports the Benefits of NAD+
While we have known about NAD+ for more than a century, in recent years some major discoveries about NAD+ have been made.
While the involvement of NAD+ in mitochondrial functions and energy metabolism are well-known, the ability of NAD+ to assist in longevity and DNA repair have been known only in the last decade.
Primary among these discoveries is that NAD+ levels decline steadily as we age, meaning other processes in the body which require NAD+ to function properly may not work as well as we age.
Another major discovery by Dr. Leonard Guarente and Dr. Shin-ichiro Imai occurred at MIT when it was found that a family of proteins which keep our cells in homeostasis, governing longevity, only function when NAD+ is present.
One recent review article studied NAD+ metabolism and oxidative stress. NAD+ was found to generate energy production and was identified as an important co-factor in cellular respiration. NAD+ was shown to play a unique role in the repair of DNA, and since there are important interactions between oxidative stress, immune activation, cell viability in neurodegenerative disorders and energy metabolism, NAD+ plays a pivotal role.
Providing NAD+ to the body in usable form, can effective regulate cell death and stress resistance associated with age-related degenerative disorders, slowing down aging and extending life. According to biologists, our goal, as human beings, is to stay in a state of homeostasis—a state of balance, made possible by coenzymes and specific proteins in the body which are metabolic “sensors,” so to speak.
Scientists have found that Sirtuin foods offer incredible health benefits, not only increasing longevity, but the overall quality of life as well.
Sirtuins are often known as the “housekeeping” genes because they are a family of age-related proteins which regulate metabolism, inflammation and cellular death, as well as longevity.
Sirtuins modulate the plasticity of the brain and improve the functions of memory formation.
Certain foods contain high levels of sirtuin activators. These foods include
Tofu and other soy products
Extra-virgin olive oil
Blackcurrants, in particular, are rich in sirtuins, and have been shown to reduce heart attack and stroke risk, even protecting the body against diabetes.
Sirtuins require NAD+ to function properly, quickly using up NAD+, requiring that the body constantly synthesize it. Researchers now believe that when NAD+ levels are properly restored, sirtuins are activated, leading to significant health benefits.
Nicotinamide riboside, has shown significant value in maintaining robust health and preventing the health problems which often accompany aging.
One study showed that one particular hallmark of aging—mitochondrial dysfunction—is the result of declining NAD+ levels, leading to a breakdown in “communication” between mitochondria and the nucleus. Nicotinamide riboside, when tested on mice, has also been shown to reverse the decline in both the number and function of adult stem cells, as well as to increase the lifespan of the animals, and the polyphenol resveratrol has been shown to be highly potent sirtuin activator.
Introducing Myetin®: The Highest Dose of NAD+ Available Without a Prescription
Myetin® is a combination of high dose biotin and NAD+ which is manufactured in an FDA approved facility under current good manufacturing practice standards.
Unlike many other NAD+ products, Myetin® uses pharmaceutical grade, pure forms of D-Biotin and NAD+ which are most effectively absorbed and utilized in the brain and the body.
Myetin® is a chewable or dissolvable tablet, which allows the NAD+ and D-Biotin to provide maximum benefits by largely bypassing the digestive system.
To be clear, Myetin® has the actual NAD+ product in it, rather than the precursor to NAD, which many other mainstream products utilize. These precursors of NAD+ have to be absorbed in the gut, pass through the liver and then what’s left, if any, will be converted into NAD+ that the body can use. This is why, when other companies talk about their NAD products, they rarely mention just how much and what type of NAD+ is actually in the product.
That’s what makes Myetin® different from other NAD+ and biotin supplements… it utilizes actual NAD+ & NOT the precursor.
Myetin® combines the regenerative energy of NAD+ with the healing properties of Biotin to provide cellular level nutrition to the body. High dose D-Biotin is the naturally occurring form of Biotin which supports the production of the myelin sheath through the production of fatty acid synthesis when administered in high dosages.
NAD+ provides the energy, D-Biotin delivers key nutrients to the body!
We believe that the body can heal itself when it has the proper assistance. It takes time to rebuild deficiencies in the body, however we are advocates of cellular level nutrition.
When the underlying symptoms of a disease or problem in the body are addressed (rather than masked by prescription drugs with potentially serious side effects), the body can do amazing things!
Because nerve damage can take many years to develop, your body will likely require some time to begin feeling the benefits of Myetin®, although studies have shown that improvement is often seen among neurodegenerative patients within a few short months.
We highly recommend that you discuss the use of Myetin® use with your physician, who can determine whether to implement Myetin® in place of your current therapies, or in conjunction with those therapies. Our team works directly with health care professionals to provide education on Myetin® which is why we advise consulting with your healthcare professional to determine whether Myetin® is right for you.
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